Profhilo contains 32mg of low molecular weight HA (80-100Kda) and 32 mg of high molecular weight HA (1100-1400Kda). This gives one of the highest concentrations of HA on the market, totalling 64 mg of HA in a 2ml prefilled syringe.
Remarkably this can still be extruded using a 29g needle.
Profhilo is developed using a patented technology resulting in hybrid cooperative complexes between high molecular weight HA and low molecular HA without using any chemical cross-linking compounds. These complexes increase the stability of HA to enzymatic and mechanical degradation.
Thermal cross-linking changes the HA’s character and behaviour, resulting in the formation of cooperative hybrid complexes which modulate the tissues. This also explains the different biological behaviour concerning H-HA and L-HA alone. One of the main advantages is longevity. Hybrid cooperative complexes have proven to be very stable with natural hyaluronidase (BTH) digestion when compared to H-HA, widely used in bio revitalisation products, or L-HA alone, resulting in the long-lasting release and the dual action of the two HA components. This dual action is ideal for remodelling skin laxity.
In Profhilo, L-HA is released slowly from the HA hybrid complexes and therefore does not trigger the first inflammatory cytokines, making it biocompatible. It also increases patient comfort during and after treatment and provides hydration to the skin – the Hydro effect.
H-HA in Profhilo provides a stable HA architecture in the dermis. This gives a volumetric effect – the Lift effect.
Another advantage of the stable cooperative hybrid complex compared to H-HA and L-HA is the increase in the expression levels of type I and type III collagen in fibroblasts and type IV and VII collagen in keratinocytes.
This results in improved skin quality and skin hydration in the dermis and epidermis. There is also increased endogenous HA and elastin production, giving the skin a more youthful look.
The nonsurgical trend that will improve how your skin looks – not only instantly – but also accumulate with longer-term results!
The days of having to go under the scalpel to give your face a youth boost are over. We’re now living in the era of injectable ‘tweakments’. There’s nothing new about using wrinkle-reducing and dermal filler injectables to reduce wrinkles and add volume to your cheeks, but now there’s a NEW injectable that will moisturise from the inside out, boosting hydration and remodelling ageing and sagging skin… say hello to Profhilo®.
The first of its kind, Profhilo® is a revolutionary beneath the skin, hyaluronic acid moisturising treatment. Its unique formulation of high and low molecular weight hyaluronic acid is one of the highest concentrations on the market. When injected into the skin it stimulates the skin cell receptors to counteract skin laxity and improve and restore the firmness of the skin.
Ultra-pure hyaluronic acid is precisely injected into the area being treated. Then, unlike wrinkle-reducing and dermal filler treatments, Profhilo® stimulates collagen and elastin, improving hydration in the deeper layers of the skin. As a stabilised product, Profhilo® has a prolonged action in the skin. During this time the stimulation of 4 different types of collagen and elastin takes place by slow release of hyaluronic acid. Results include the improvement of the skin’s texture, firmness and radiance in addition to reducing the appearance of fine lines and wrinkles.
Profhilo® can be used by patients of all ages and is the perfect solution if you’re looking for a youth boost for your skin but don’t want dermal fillers or wrinkle relaxing treatment. The injections are strategically placed at key points to rejuvenate the skin’s own collagen-making abilities. It can be used on numerous areas such as the face, hands, neck, and chest and it can be used on its own or in combination with other aesthetics treatments currently on offer. Two treatments are recommended, spaced four weeks apart, and you’ll see the benefits from six-nine months.
The powerful moisturising properties and hyaluronic acid combat the signs of fine lines and wrinkles whilst deeply hydrating the skin and restoring a youthful glow. The stimulation (after having the Profhilo® treatment) results in significant tissue improvement. This means we cannot say that Profhilo® is a skin booster as it also has a significant tightening and lifting effect on the tissue. It is a great ‘first step’ treatment as it acts directly on skin laxity and can also improve the appearance of uneven skin tone, pores and dull pigmented skin as part of a bespoke skin programme.